Comprehensive medical guide to Zoloft (Sertraline): how it works, dosage, safety, patient experience, cost, and therapy comparisons. Learn when and how to use sertraline safely. Description Sertraline is used to treat depression, obsessive-compulsive disorder (OCD), panic disorder, premenstrual dysphoric disorder (PMDD), posttraumatic stress disorder (PTSD), and social anxiety disorder (SAD). Sertraline belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). It works by increasing the activity of a chemical called serotonin in the. See risks & benefits. Learn more about ZOLOFT® (sertraline HCl), a prescription treatment for depression. Zoloft is a selective serotonin reuptake inhibitor (SSRI) used to treat depression and other conditions. Learn how Zoloft works, its side effects, and precautions. Find out how Zoloft is used to treat anxiety, its effectiveness, dosage, side effects, and when it may be the right option for you. Zoloft is an antidepressant used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, and post-traumatic stress disorder. Find patient medical information for Sertraline (Zoloft) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Sertraline is an SSRI used for depression, OCD, panic disorder, PTSD and PMDD. See usual doses, side effects, interactions and 4,600+ patient reviews. Sertraline, sold under the brand name Zoloft among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class [11] used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, obsessive–compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder. [12] Sertraline Tablets Sertraline (Zoloft) is a medication that increases the amount of serotonin in your brain. Serotonin is a hormone that helps regulate your mood. It treats depression, anxiety, obsessive-compulsive disorder, post-traumatic stress disorder and premenstrual dysphoric disorder.